Yes, you can take inositol while on metformin. Inositol is a vitamin-like supplement that helps people with polycystic ovary syndrome (PCOS) to regulate cycles, restore hormone balance, and improve ovulation. It can also help manage blood sugar, cravings, and lower insulin levels, which can reduce the risk of type 2 diabetes. You can take inositol if you are taking metformin because they work differently. A study published in the Evidence-Based Women's Health Journal looked at 128 women with PCOS who took 1500 mg metformin or myo + d-chiro inositol (in a 40:1 ratio) daily for 3 months. The results showed that myo + DCI showed significantly better results in weight reduction, ovulation, and pregnancy rates (46.7% vs. 11.2%) than metformin. MYO compared with Metformin a systematic review and meta analysis looked at six trials with a total of 355 patients with PCOS. They found similar results with patients who took myo inositol when compared with metformin. Both groups improved insulin and testosterone levels similarly.