What is Ozempic?
Ozempic, known chemically as exenatide, is a synthetic version of the hormone glucose-dependent insulinotropic polypeptide (GIP). It is a member of the GLP-1 family of incretins, which are hormones that help regulate blood sugar levels. Ozempic belongs to the class of long-acting GLP-1受体激动剂 (GLP-1 RAs), which are designed to mimic the natural GLP-1 hormone in the body to provide sustained improvement in glycemic control.
indications
Ozempic is typically used to treat type 2 diabetes in combination with other antidiabetic drugs. It is also being studied for its potential use in weight loss and weight management. Ozempic is not approved for use in individuals with type 1 diabetes.
dosing
The recommended starting dose of Ozempic in adult patients with type 2 diabetes is 10 micrograms (μg) subcutaneously (SC) once daily. Doses may be increased based on individual response and safety monitoring. It is important to avoid injecting into areas of skin with a high risk of infection, such as around the waistline, buttocks, or sites that have recently been cut or wounded.
contraindications
Ozempic is contraindicated in individuals with a history of allergic reaction to exenatide or any of its components. It is also contraindicated in patients with active or history of pancreatitis, or those with any other chronic pain condition. People with a history of severe psychiatric disorders, such as depression or anxiety, may also be at risk.
adverse reactions
Common adverse reactions associated with Ozempic include:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Headache
- Injection-site reactions
interactions
Concurrent use of Ozempic with certain medications may lead to interactions. Some examples include:
- Serotonin reuptake inhibitors (SSRIs): May increase the risk of hypoglycemia
- Lithium carbonate: May affect glucose homeostasis
- Diabetic sulfonylureas: May reduce glucose-lowering effect of Ozempic
It is important to inform your healthcare provider about all medications you are taking, including vitamins, over-the-counter products, and any other drug or herbal supplements, to avoid potential drug interactions.
costs
The cost of Ozempic can vary depending on the formulation and the quantity purchased. In the United States, the average cost per patient for a 30-day supply of Ozempic according to 2021 data is between $80 and $120 USD. However, the cost may be higher or lower depending on factors such as the brand name, dosage form, and the particular retail outlet.
conclusion
Ozempic (exenatide) is a synthetic GLP-1 receptor agonist used to treat type 2 diabetes. It works by mimicking the actions of endogenous GLP-1, which stimulates insulin production, slows gastric emptying, and promotes satiety. Ozempic is typically used in combination with other antidiabetic drugs to improve glycemic control and may also be used for weight loss. Side effects of Ozempic are generally mild and can be managed by reducing the dosage or changing the injection site. The cost of Ozempic can vary and may be covered by insurance, depending on the specific circumstances and coverage guidelines. Discuss any concerns with your healthcare provider before initiating treatment with Ozempic.
