Last Update: September 10, 2023
AMBRIEN® (zolpidem) is a prescription-only sleep medication approved by the US Food and Drug Administration (FDA) to aid in the short-term treatment of nocturnal sleep disruptions in adults. It is a non-benzodiazepine drug that works by binding to the gamma-aminobutyric acid type A (GABA-A) receptors, which are responsible for regulating neurotransmitter release throughout the brain. ThisBinding potentiates the action of endogenous GABA, leading to the opening of chloride channels, which in turn causes the cell to hyperpolarize and become less responsive to further excitatory inputs. This effect results in a calming and Relaxation effect. AMBIEN is available in doses ranging from 5 mg to 20 mg, with the suggested dosage usually being between 5 mg to 10 mg based on the individual needs of the patient.
AMBRIEN is typically used for the temporary relief of insomnia, which includes difficulty initiating sleep, maintaining sleep, or early morning awakening. It is also employed as a preoperative medication to help patients relax before a surgical procedure. Additionally, it may be used off-label to treat other conditions such as anxiety disorders, restless leg syndrome, and sleepwalking.
AMBRIEN should not be used as a routine treatment for chronic insomniac attacks. Ambien has a potential for addiction and dependency, which is why it's crucial to only take it on an as-needed basis. Additionally, Ambien is a controlled substance and belongs to the Federal Drug Administration's (FDA) prescription category C. Ambien CR (combination of ambenonium bromide and zolpidem) is a shorter-acting form of Ambien that can be dispensed without a prescription in some states. However, individuals taking Ambien should avoid engaging in activities that require alertness or coordination following bedtime consumption.
AMBRIEN is contraindicated in individuals with a known history of substance abuse or addiction to prescription zolpidem or other benzos. In addition, those with a significantly reduced GABA-A receptor function or myasthenia gravis should avoid Ambien due to an increased risk of side effects.
Safety and efficacy of AMBIEN have not been established in children and adolescents under the age of 18. Furthermore, patients with sleep apnea should avoid Ambien, unless they have been evaluated and determined stable on a ventilator-free regimen by a sleep specialist.
Ambient temperature and humidity must be maintained constant throughout the packaging and shipping process to minimize the risk of ambornyl degradation. It is important to store Ambien as directed by the manufacturer to ensure that the medication remains potent and effective, as Ambien can lose its potency when exposed to heat or moisture.
AMBRIEN comes in several different strengths that may be chosen based on the individual needs of the patient. These strengths include 5mg, 10mg, 15mg, and 20mg. The dosage should be adjusted based on the response of the patient and the advice of the healthcare provider.
Potential side effects of Ambien include drowsiness, dizziness, difficulty concentrating, lightheadedness, and an upset stomach. These side effects are most common when Ambien is first administered. While most of these side effects are temporary and subside within a few days of continuous use, some individuals may experience persistent symptoms that can lead to reduced quality of life or even serious health issues. These side effects can also affect cognitive performance and may increase the risk of accidents and injuries.
It is crucial to consult with a healthcare provider before taking Ambien to ensure that the medication is safe and appropriate for individual needs. healthcare providers can work with individuals to determine the appropriate dose, frequency, and duration of therapy, as well as monitor for any potential adverse reactions or drug interactions.
In conclusion, Ambien, an FDA-approved prescription medication, is often used to help individuals with insomnia to fall asleep and stay asleep. It acts by enhancing the effects of γ-aminobutyric acid, a neurotransmitter that promotes relaxation. While Ambien has been used safely by some people, it can also cause serious side effects. Always consult with a healthcare provider before taking Ambien, and follow the medication's instructions carefully to prevent potential complications.
AMBRIEN is a medication approved for short-term use in the treatment of insomnia. It is a controlled substance and requires a prescription from a healthcare provider. AMBARIEN should only be taken on an as-needed basis and should never be shared with others. Potential Side Effects of AMBARIEN include drowsiness, dizziness, nausea, vomiting, and constipation. These side effects can occur within the first few days of starting ambien and typically subside within a few weeks. AMBARIEN is contraindicated in individuals with a history of substance abuse or addiction to prescription zolpidem or other benzos, in those with significant breathing problems, and in children and adolescents under 18 years of age. It is important to tell your healthcare provider about any other medications you are taking, including over-the-counter and prescription drugs, vitamins, and herbs, to avoid potential drug interactions. Ambien may also interact with other drugs that can reduce cognitive function or increase the risk of falls, so it is crucial to consult with your healthcare provider before starting ambien therapy. With proper use and monitoring, AMBARIEN can be a safe and effective treatment option for insomnia in adults, but it is essential to avoid unnecessary use or abuse. Always refer to the medication guide provided by your healthcare provider for dosing instructions and potential side effects, and to inform your healthcare provider about any unexpected or severe side effects to ensure your safety and well-being.
AMBRIEN uses:
- Temporarily aids in falling asleep and staying asleep.
- Often used as a preoperative medication.
- Treatment of restless leg syndrome.
- Treatment of sleepwalking.
- May be used for the short-term relief of central sleep apnea in adults.
AMBRIEN should not be used for longer than is necessary, and it is essential to consult with healthcare providers regularly. Always adhere to the dosing schedule and do not increase the dose without consulting with your healthcare provider. It is also important to speak with healthcare providers before starting Ambien therapy if you have history of substance abuse or addiction to benzos, if you have sleep disturbances associated with chronic obstructive pulmonary disease (COPD), sleep apnea, significant hearing loss, myasthenia gravis, or if you are also treated with valproic acid ( depakote).
*AMBRIEN should always be stored upright, away from heat and humidity, to minimize the risk of degradation. Do not store Ambien in direct sunlight. Ambien is usually taken orally, but can also be administered vaginally (vaginally).
AMBRIEN may be taken with or without food and is typically best taken at bedtime. Always follow the dosing instructions provided by your healthcare provider.
AMBRIEN interactions:
- Benzodiazepines: May increase risk of respiratory depression.
- Selective serotonin reuptake inhibitors (SSRIs): May reduce the effectiveness of Ambien.
- Serotonin norepinephrine reuptake inhibitors (SNRIs): May affect Ambien levels.
- Antihypertensive drugs: Could exacerbatehypotension.
- Cigarette smoking and alcohol: May increase Ambien's effects.
- Non-benzodiazepines: Limited information is available on their effects when used with Ambien.
- Other drugs: The effects of Ambien may be altered by numerous other chemicals.
*AMBRIEN is a medication that belongs to a class of drugs called non-benzodiazepines (Z-drugs). Ambien is chemically modified from the compound ethyl-beta-carboline carboxylate (beta-CCE), which was discovered serendipitously and named after Ethanol, hence the ethanolamine part of the name. The chemical structure of Ambien is shown below. Ambien contains the alcohol moiety, beta CCE, and the pyridinium ring structure. *
AMBRIEN DEPRECRIPTION:
- ZOLPIDEMTartrate
- Chemical Formula: [(+)-7-(2-chlorophenyl)-N,N-dimethyl-5-(2,3-dichlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one]
- CAS注册号: 58-61-74-8
- 药物分类：苯二氮卓类药物（Non-Benzodiazepines）
AMBRIEN PRESCRIPTION INFORMATION:
- 用途：治疗短期失眠。
- 剂量：5mg-20mg。根据个体需要调整剂量。
- 预防耐药性：不应超过推荐剂量。
- 不良反应：最常见的不良反应为嗜睡、头晕、恶心和呕吐。
- 过量症状：可能导致认知功能下降、呼吸抑制。
- 禁忌症：对阿片类药物滥用史患者禁用。
AMBRIEN注意事项（警告与注意事项）：
- 非处方药物使用时需遵循医嘱。
- 可能导致嗜睡，驾驶机动车或操作危险机械时避免使用。
- 如需要服用其他药品，请先向医生咨询。
- 孕妇及哺乳期妇女应慎用。
