propofol bottle
propofol is a general anesthetic commonly used in medical procedures. it is a clear, colorless, and sweet-tasting liquid that is derived from the oil of soybean. propofol is an ester that belongs to the class of alkanes and alkenes, featuring a molecular weight of 252.46 g/mol and a molecular formula of C9H17OCOCH3.
this article aims to discuss the importance of shaking propofol bottles before use, its stability concerns, and handling and storage recommendations. propofol bottle characteristics are also briefly described.
importance of shaking propofol bottles
propofol must be shaken well before use to ensure an even suspension of propofol molecules across the aqueous phase. if the propofol emulsion is not shaken, it may result in uneven drug distribution within the solution. shaking also helps to distribute the contents accurately in the container, so that the precise required amount of the drug is used for the intended procedure. the distribution of propofol in the bottle will determine the rate of release of the drug as the needle is inserted into the skin, which is essential to minimize discomfort and pain during infiltration or infiltration.
stability concerns
propofol bottle stability may vary depending on its shelf life following reconstitution, and the drug's shelf life varies. propofol emulsion does not support the growth of microorganisms, with an absolute minimum of 24 to 48 hours, regardless of the length of the reconstituted solution or the amount of time it is stored.
however, propofol emulsion may support the growth of microorganisms during its shelf life if not stored under ideal conditions. the presence of the preservative (EDTA) in propofol is essential to inhibit the rate of microorganis growth.
if propofol bottle is stored in a cool, dark place, it can remain stable for up to 3 years after reconstitution.
propofol bottles stored properly are typically stable for 9 months.
handling and storage recommendations
proper handling and storage of propofol bottles are essential for preserving their quality and effectiveness. when storing propofol, it must be away from light or UV exposure to avoid degradation. if bottles are stored at 2° to 8°C, they can be protected from light, allowing them to retain stability for up to 9 months.
it is essential to protect propofol from extreme temperatures, such as bright sunshine, to minimize degradation. keeping propofol bottles in an upright position in a dark place will help keep light exposure to a minimum. it is also important to ensure that the caps are tightly closed to prevent contamination.
propofol tubes can be stored in a refrigerator for a shorter period. storing at −15°C ± 2°C is recommended to protect the product from the harmful effects of prolonged exposure to direct sunlight for long periods or extreme fluctuations in temperature.
propofol bottles in storage under normal conditions remain valid for 24 months after reconstitution.
propofol bottles should not be frozen but can remain stable at −20°C for up to 5 years.
###propofol瓶是一种用于医学治疗的通用麻醉剂，必须在使用前充分摇匀以确保药物的均匀分布。储存和运输时，应避免强光照射和极端温度变化以保护药品质量。正确的储存条件有助于延长药物的有效期，确保临床效果。