Yes, hyaluronic acid may increase estradiol levels in the body, although its effect on estradiol levels is inconsistent and may vary from person to person.
Hyaluronic acid (HA) is a natural polysaccharide that is found in various tissues, such as skin, hair, and connective tissue. It acts as a cushioning material and shock absorber in the body.
In women, HA levels tend to decrease as they approach menopause, which can lead to signs and symptoms of vulvovaginal atrophy, such as dryness and itching. Additionally, low levels of HA in the vagina can affect vaginal health and function due to its lack of cushioning ability.
Hyaluronic acid treatment, which involves applying a gel or cream containing HA topically to the vulvovaginal area, has been used to alleviate signs and symptoms of vulvovaginal atrophy.
Some studies have explored theeffect of HA on estradiol levels in women undergoing menopause. One study found that daily use of a HA vaginal cream for 12 weeks increased estradiol levels by 20% compared to Placebo in postmenopausal women with vulvovaginal atrophy. Another study found that in postmenopausal women with atrophic vaginitis, daily use of a HA vaginal suppository for 8 weeks increased estradiol levels by 27% compared to Placebo.
However, other studies have found no effect on estradiol levels with HA treatment in postmenopausal women.
It is important to note that the effectiveness and safety of HA for the treatment of vulvovaginal atrophy depend on factors such as the individual differences in the response to HA, the severity of symptoms, and the dosage and duration of HA treatment.
It is always recommended to consult with a healthcare provider before starting any new therapy, including the use of HA for the treatment of vulvovaginal atrophy.
